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Ethnic variation of fetal nasal bone length between 11–14 weeks' gestation
Author(s) -
Collado Fadi,
Bombard Allan,
Li Vuysan,
Julliard Kell,
Aptekar Leslie,
Weiner Zeev
Publication year - 2005
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1195
Subject(s) - gestation , fetus , medicine , obstetrics , variation (astronomy) , nasal bone , gestational age , ethnic group , pregnancy , biology , anatomy , genetics , physics , sociology , astrophysics , anthropology
Objective We sought to compare the fetal nasal bone length (FNBL) between different ethnic groups at 11–14 weeks' gestation. Methods FNBL and the FNBL/CRL ratio were measured in patients undergoing first trimester ultrasound for nuchal translucency (NT) and the ethnicity of the patient was recorded under four categories: non‐Hispanic White, non‐Hispanic black, Hispanic, and Chinese. Results Two hundred and one patients were included in the study. Measurement of the FNBL could not be obtained in nine patients (4.5%) and foetal nasal bone was absent in one fetus. Comparing the four groups, non‐Hispanic White, non‐Hispanic Black, Hispanic, and Asian, there were no statistical differences in crown‐rump length (61 ± 14 mm; 68.6 ± 15 mm; 60.2 ± 14 mm; 62.4 ± 8.8 mm, respectively) or the NT (1.3 ± 0.5 mm; 1.25 ± 0.4 mm; 1.35 ± 1 mm; 1.4 ± 0.4 mm, respectively). However, the FNBL (2.9 ± 0.7 mm; 2.5 ± 0.6 mm; 2.5 ± 0.6 mm; 2.2 ± 0.4 mm, respectively, p < 0.01) and the FNBL/CRL ratio (0.049 ± 0.01, 0.045 ± 0.01, 0.043 ± 0.01, 0.037 ± 0.01, respectively, p < 0.01) were both statistically different, when comparing between these groups. Conclusion If the FNBL is to be introduced into first‐trimester screening, it should be adjusted for ethnicity. Copyright © 2005 John Wiley & Sons, Ltd.