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Lobar holoprosencephaly: prenatal MR diagnosis with postnatal MR correlation
Author(s) -
Wong Alex M.C.,
Bilaniuk Larissa T.,
Ng K.K.,
Chang Y.L.,
Chao A.S.,
Wai Y.Y.
Publication year - 2005
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1108
Subject(s) - holoprosencephaly , corpus callosum , prenatal diagnosis , agenesis , agenesis of the corpus callosum , medicine , magnetic resonance imaging , gestation , corpus callosum agenesis , fetus , anatomy , pathology , pregnancy , radiology , biology , genetics
Holoprosencephaly is a congenital anomaly characterized by lack of cleavage of the prosencephalon. Although, relatively rare, it is the most common anomaly that involves both the brain and the face. Prenatal diagnosis of this anomaly using ultrasonography, particularly of the less severe forms, is difficult. Magnetic resonance imaging has recently become an important complement to US in prenatal diagnosis of CNS anomalies. We herein report a patient in whom, at 23 weeks of gestation, US suggested agenesis of the corpus callosum and in whom, at 24 weeks of gestation, MRI correctly diagnosed lobar holoprosencephaly, which was confirmed by a postnatal MRI at 3 weeks of age. Copyright © 2005 John Wiley & Sons, Ltd.