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The COMT gene variant is associated with depression's decreased positive affect symptoms in C hinese adults
Author(s) -
Cao Chengqi,
Wang Li,
Wang Richu,
Qing Yulan,
Zhang Jianxin,
Wu Gwyneth Winnie Y.
Publication year - 2014
Publication title -
psych journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 14
eISSN - 2046-0260
pISSN - 2046-0252
DOI - 10.1002/pchj.63
Subject(s) - depression (economics) , single nucleotide polymorphism , affect (linguistics) , snp , genotype , extant taxon , center for epidemiologic studies depression scale , epidemiology , medicine , polymorphism (computer science) , psychology , clinical psychology , psychiatry , oncology , genetics , depressive symptoms , gene , biology , cognition , macroeconomics , communication , evolutionary biology , economics
This study examined the association between the COMT V al 158 M et genotype and depression symptoms. A total of 326 C hinese adults who experienced the deadly 2008 Wenchuan earthquake and lost children during the disaster participated in this study. Depression symptoms were measured using the Center for Epidemiological Studies Depression Scale ( CES‐D ). The single nucleotide polymorphism ( SNP ) was successfully genotyped using the MassARRAY system. Results indicated that although the V al 158 M et genotype was not associated with total depression symptoms, it was significantly correlated with decreased positive affect symptoms of depression in males. The findings indicated that COMT may play an important functional role in the development of depression, and contribute to the extant knowledge of the genetic basis and sex‐specific expression of symptoms in depression.