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Identification of antioxidant phenolic compounds in feverfew ( Tanacetum parthenium ) by HPLC‐ESI‐MS/MS and NMR
Author(s) -
Wu Changqing,
Chen Feng,
Wang Xi,
Wu Yonnie,
Dong Meidui,
He Guoqing,
Galyean Ronald D.,
He Lilin,
Huang Guohui
Publication year - 2007
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/pca.995
Subject(s) - chemistry , dpph , polyphenol , antioxidant , chromatography , high performance liquid chromatography , herb , scavenging , organic chemistry , traditional medicine , medicinal herbs , medicine
Antioxidant polyphenolic acids in the medicinal herb feverfew ( Tanacetum parthenium ) were isolated through in vitro bioassay‐orientated antioxidant tests in response to 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH • ) free radical scavenging and Fe 2+ ‐chelating activities. Purification of the active compounds and their structural elucidation involved a variety of techniques including open‐column chromatography, HPLC, GC‐MS, LC‐MS and NMR. Major compounds with potent DPPH • scavenging activities were characterised as 3,5‐, 4,5‐ and 3,4‐di ‐O‐ caffeoylquinic acids (DCQAs). This is the first report of DCQAs found in feverfew. Copyright © 2007 John Wiley & Sons, Ltd.