Dereplication of pentacyclic triterpenoids in plants by GC‐EI/MS | Zendy

Gu JianQiao | Zendy; Wang Yuehong | Zendy; Franzblau Scott G. | Zendy; Montenegro Gloria | Zendy; Timmermann Barbara N. | Zendy

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Dereplication of pentacyclic triterpenoids in plants by GC‐EI/MS

Author(s) -

Gu JianQiao,

Wang Yuehong,

Franzblau Scott G.,

Montenegro Gloria,

Timmermann Barbara N.

Publication year - 2006

Publication title -

phytochemical analysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 72

eISSN - 1099-1565

pISSN - 0958-0344

DOI - 10.1002/pca.892

Subject(s) - chemistry , ursolic acid , betulinic acid , oleanolic acid , triterpenoid , terpene , gas chromatography–mass spectrometry , triterpene , chromatography , stereochemistry , mass spectrometry , medicine , genetics , biology , alternative medicine , pathology

Three common plant‐derived pentacyclic triterpenoids, oleanolic acid ( 1 ), betulinic acid ( 2 ) and ursolic acid ( 3 ), have been found to exhibit moderate anti‐tubercular activity in a microplate alamar blue assay. In order to facilitate the discovery of novel anti‐tubercular leads with diverse chemical structures, a new and rapid GC‐EI/MS method was developed simultaneously and unambiguously to dereplicate 1–3 as their methyl esters with limits of detection of 25.6, 26.9 and 26.8 ng, respectively. Copyright © 2006 John Wiley & Sons, Ltd.

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