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An NMR method towards the routine chiral determination of natural products
Author(s) -
Jaki Birgit,
Franzblau Scott,
Pauli Guido F.
Publication year - 2004
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/pca.760
Subject(s) - chemistry , natural (archaeology) , chromatography , archaeology , history
State‐of‐the‐art structure elucidation and dereplication of natural products is incomplete without the determination of enantiomeric purity, especially when compounds are to be biologically evaluated. An NMR procedure is presented in order to distinguish and determine enantiomers in natural product samples. The method is also of value in the structure elucidation process by providing information, which is otherwise of a non‐routine nature. Using enantiomeric 1‐acetoxychavicol acetates and carvones as model compounds, this study presents a chiral NMR procedure that allows distinction and determination of chiral antipodes of natural products in a routine set‐up. Copyright © 2004 John Wiley & Sons, Ltd.