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HPLC‐NMR/HPLC‐MS analysis of the bark extract of Stauranthus perforatus
Author(s) -
Setzer William N.,
Vogler Bernhard,
Bates Robert B.,
Schmidt Jennifer M.,
Dicus Christopher W.,
Nakkiew Pichaya,
Haber William A.
Publication year - 2003
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/pca.687
Subject(s) - chemistry , imperatorin , high performance liquid chromatography , chromatography , bark (sound) , dichloromethane , quinoline , simaroubaceae , stereochemistry , organic chemistry , physics , solvent , acoustics
A combination of HPLC‐MS and HPLC‐NMR techniques has been used to analyse the cytotoxic fractions of the dichloromethane extract of bark of Stauranthus perforatus . Six furanocoumarins (byakangelicol, heraclenin, heraclenol, imperatorin, isopimpinellin and xanthotoxin) and nine quinoline alkaloids (two known compounds, veprisine and 5‐hydroxy‐1‐methyl‐2‐phenyl‐4‐quinolone, along with seven novel compounds, stauranthine, 3′,4′‐dihydroxy‐3′,4′‐dihydroveprisine, 3′,4′‐dihydroxy‐3′,4′‐dihydrostauranthine, 3′,6′‐dihydroxy‐3′,6′‐dihydroveprisine, 3′,6′‐dihydroxy‐3′,6′‐dihydrostauranthine, 6′‐hydroxy‐3′‐ketoveprisine and 6′‐hydroxy‐3′‐ketostauranthine) have been identified in the fractions. Copyright © 2003 John Wiley & Sons, Ltd.