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HPLC isolation of the anti‐plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata
Author(s) -
Tshibangu Jeannette Ndaya,
Wright Anthony D.,
König Gabriele M.
Publication year - 2003
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/pca.673
Subject(s) - chemistry , isolation (microbiology) , high performance liquid chromatography , chromatography , microbiology and biotechnology , biology
The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum . In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd.