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Concentrations of taxol and related taxanes in the needles of different Taxus cultivars
Author(s) -
Elsohly Hala N.,
Croom Edward M.,
Kopycki Wlodzimierz J.,
Joshi Alpana S.,
Elsohly Mahmoud A.,
McChesney James D.
Publication year - 1995
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/pca.2800060307
Subject(s) - cultivar , chemistry , taxane , taxus , ornamental plant , horticulture , botany , chromatography , biology , breast cancer , cancer , genetics
The taxane content of the needles of 57 cultivars obtained from five major nurseries in the United States is presented. The analysis of taxol (1), and five other related taxanes, 10‐desacetyl‐7‐epi‐taxol (2), cephalomannine (3), 10‐desacetyl taxol (4), baccatin III (5) and 10‐desacetyl baccatin III (6) was carried out using a high performance liquid chromatographic method developed in our laboratory. The results of these analyses showed that the total “useful” taxanes varied between 0.0232%‐0.113%, with 1 and 6 being the most abundant taxanes. The survey identified 11 cultivars with a content of 1 ranging from 0.028% to 0.062%, and ten cultivars with a content of 6 ranging from 0.028% to 0.066%; 3 and 4 each represented approximately 30%‐50% of the concentration of taxol in most cultivars. Therefore, the needles of ornamental Taxus represent a significant, rich and renewable source for taxol and other related taxanes.