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Antitrypanosomal Activity of a Novel Taccalonolide from the Tubers of Tacca leontopetaloides
Author(s) -
Dike Vivian T.,
Vihiior Burbwa,
Bosha Joel A.,
Yin Tung Mei,
Ebiloma Godwin Unekwuojo,
Koning Harry P.,
Igoli John O.,
Gray Alexander I.
Publication year - 2016
Publication title -
phytochemical analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 72
eISSN - 1099-1565
pISSN - 0958-0344
DOI - 10.1002/pca.2619
Subject(s) - trypanosoma brucei , chemistry , column chromatography , in vitro , chromatography , biochemistry , gene
Several taccalonolides with various bioactivities have been isolated from Tacca species but no studies to isolate taccalonolides with anti‐trypanosomal activity from Tacca leontopetaloides have been reported. Objectives To analyse extracts of the roots of Tacca leontopetaloides , purify the extracts by column chromatography and identify isolated compounds by spectroscopic methods. The compounds and fractions will be tested for antitrypanosomal activity in vitro against Trypanosoma brucei brucei . Material and methods Dried roots or tubers of Tacca leontopetaloides , chromatographic separation and spectroscopic identification. Results A novel taccalonolide A propanoate and some known taccalonolides were isolated and their structures were determined by NMR and mass spectrometry Conclusion Several taccalonolides were isolated from Tacca leontopetaloides and were found to have in vitro antitrypanosomal activity against Trypanosoma brucei brucei and EC 50 values for the isolated compounds were from 0.79 µg/mL. Copyright © 2016 John Wiley & Sons, Ltd.