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Montmorillonite‐lecithin‐heparin/PDMS films with enhanced mechanical and antithrombogenic properties
Author(s) -
Meng Na,
Zhang Ming,
Ge Man Qing,
Zhou Ninglin,
Chi Cheng,
Chu Xiaohong,
Sun Baohong,
Gao Xiaojun
Publication year - 2020
Publication title -
polymer composites
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.577
H-Index - 82
eISSN - 1548-0569
pISSN - 0272-8397
DOI - 10.1002/pc.25513
Subject(s) - materials science , montmorillonite , intercalation (chemistry) , scanning electron microscope , hemolysis , polymer , chemical engineering , polymer chemistry , nuclear chemistry , composite material , chemistry , organic chemistry , engineering , immunology , biology
This study developed a polymer/layered silicate film as blood‐contacting devices. First, the lecithin‐heparin (LEC‐HEP) was used to modify pristine montmorillonite (MMT). LEC‐HEP was successfully exchanged in the MMT. The organically modified MMT was used for the synthesis of poly(dimethylsiloxane) (PDMS)/MMT‐LEC‐HEP films by intercalation solution technique. The morphological, structural of the prepared film were evaluated using X‐ray diffraction, scanning electron microscopy. LEC‐HEP‐MMT concentration of 0.5 wt% in PDMS systems enhanced mechanical properties. The hemocompatibility of PDMS/LEC‐HEP‐MMT films was evaluated by hemolysis assay, dynamic coagulation time, and plasma recalcification time (PRT). PDMS/0.5 wt% LEC‐HEP‐MMT films also exhibited higher blood anticoagulant indexes, longer the PRT and lower hemolysis rate than the corresponding PDMS film.