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Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid)
Author(s) -
Dong Wenyuan,
Zeng Qinhuan,
Yin Xueqiong,
Liu Haifang,
Lv Ju,
Zhu Li
Publication year - 2018
Publication title -
polymer composites
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.577
H-Index - 82
eISSN - 1548-0569
pISSN - 0272-8397
DOI - 10.1002/pc.24500
Subject(s) - materials science , compatibility (geochemistry) , lactic acid , chitosan , polylactic acid , composite material , electrospinning , nanofiber , chemical engineering , polymer , genetics , bacteria , engineering , biology
Chitosan nanopowder (NCTS) was prepared through ball milling. NCTS was successfully electrospun to nanofibers with the assistance of poly(lactic acid) (PLA) to prepare electrospun mats (NCTS/PLA). Scanning electron microscope images revealed that there were no chitosan particles in NCTS/PLA, indicating NCTS had been stretched to nanofibers. The effects of the electrospinning parameters (voltage, distance, and NCTS amount) on the morphology of NCTS/PLA were investigated. X‐ray photoelectron spectroscopy verified the existence of chitosan in the mats. All the NCTS/PLA mats had a water contact angle higher than 130°, showing good hydrophobicity. NCTS/PLA expressed good blood compatibility according to the results of coagulation time and platelet adhesion experiment. NCTS/PLA had a little longer activated partial thrombin time than PLA and more NCTS leaded longer coagulation times. No platelets aggregation and deformation appeared on NCTS/PLA mats. POLYM. COMPOS., 39:E416–E425, 2018. © 2017 Society of Plastics Engineers