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Morphological, thermal, and blood‐compatible properties of electrospun nanocomposites for tissue engineering application
Author(s) -
Manikandan Ayyar,
Mani Mohan Prasath,
Jaganathan Saravana Kumar,
Rajasekar Rathanasamy
Publication year - 2018
Publication title -
polymer composites
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.577
H-Index - 82
eISSN - 1548-0569
pISSN - 0272-8397
DOI - 10.1002/pc.24463
Subject(s) - materials science , nanocomposite , polyurethane , composite material , clotting time , partial thromboplastin time , compatibility (geochemistry) , composite number , scaffold , biomedical engineering , coagulation , medicine , psychology , psychiatry
In this work, the morphological, thermal, and blood compatibility properties of prepared polyurethane (PU) and gandharvahasthadi eranda thailam (GHT) nanocomposites were investigated. Morphological and thermal characterization revealed reduced diameter, improved surface roughness, and higher thermal degradation compared to control. The activated partial thromboplastin time (APTT) and prothrombin time (PT) assay revealed that the fabricated nanocomposites displayed delayed blood clotting time owing to improved surface morphology. The hemolytic assay suggested that nanocomposites would be nonhemolytic material due to low hemolytic index of about 1.15% compared to pure PU (2.733%) portraying its safety with the red blood cells. Thus, the newly developed PU/GHT composite scaffold possessing better physicochemical and blood compatibility may be considered as a potential substitute scaffold for replacing damaged tissue. POLYM. COMPOS., 39:E132–E139, 2018. © 2017 Society of Plastics Engineers