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Preparation of novel pH‐sensitive nanocomposites based on ionic‐liquid modified montmorillonite for colon specific drug delivery system
Author(s) -
Mahkam Mehrdad,
Abbaszad Rafi Abdolrahim,
Mohammadzadeh Gheshlaghi Leila
Publication year - 2016
Publication title -
polymer composites
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.577
H-Index - 82
eISSN - 1548-0569
pISSN - 0272-8397
DOI - 10.1002/pc.23169
Subject(s) - montmorillonite , nanocomposite , materials science , monomer , ionic liquid , drug delivery , naproxen , methacrylic acid , methacrylate , methyl methacrylate , chemical engineering , polymer chemistry , fourier transform infrared spectroscopy , nuclear chemistry , drug carrier , polymer , organic chemistry , chemistry , composite material , nanotechnology , medicine , alternative medicine , pathology , engineering , catalysis
An ionic liquid monomer, 3‐methyl‐1‐[2‐(2‐methyl‐acryloxy)‐ethyl]‐imidazolium chloride, was synthesized through the quaternization of N ‐methylimidazole and 2‐chloroethyl methacrylate. This ionic liquid monomer intercalated into the montmorillonite layers and subsequently copolymerized with methacrylic acid. The organic–inorganic composite was characterized by FTIR, XRD, SEM, and EDX to study their structure and properties. Naproxen as a model drug was entrapped in these pH‐sensitive positively charged nano carriers and the in vitro release profiles were established separately in both enzyme‐free simulated gastric and intestinal fluids (SGF, pH 1) and (SIF, pH 7.4) respectively. It was observed that the drug release percentages in SIF were higher; hence the prepared nanocomposite could be considered as a suitable carrier for colon specific drug delivery. POLYM. COMPOS., 182–187, 2016. © 2014 Society of Plastics Engineers