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Sustained delivery of hydrocortisone acetate by CS/N‐vinyl‐2‐pyrrolidone/CaCO 3 microparticle hybrid hydrogels
Author(s) -
Mostafa Tahia B.,
ElSigeny Samia,
Abou Taleb Manal F.
Publication year - 2014
Publication title -
polymer composites
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.577
H-Index - 82
eISSN - 1548-0569
pISSN - 0272-8397
DOI - 10.1002/pc.22765
Subject(s) - self healing hydrogels , swelling , materials science , vinyl acetate , chemical engineering , composite number , chitosan , drug delivery , aqueous solution , microparticle , hydrocortisone acetate , nuclear chemistry , composite material , polymer chemistry , hydrocortisone , chemistry , nanotechnology , polymer , organic chemistry , copolymer , biochemistry , engineering
The goal of this research is to develop a composite hydrogel system for sustained release of therapeutic agents. The hybrid hydrogels were prepared by radiation crosslinking on aqueous solution of Chitosan (CS)/ N ‐vinyl‐2‐pyrrolidone (NVP) with different loads of CaCO 3 in the presence of hydrocortisone acetate (HCA), an anti‐inflammatory drugs. Physical characteristics of CS/NVP/CaCO 3 were studied using X‐ray diffraction (XRD) and infrared spectrophotometery (IR). The porous structure of resulted hydrogel was confirmed by SEM micrographs. The effect of doses and calcium carbonate amount on the swelling of the hydrogels was investigated. The ability of the prepared CS/NVP/CaCO 3 ‐based hybrid hydrogels to be used as drug carriers for anti‐inflammatory‐specific drug delivery system was estimated using HCA as a model drug. POLYM. COMPOS., 35:1176–1183, 2014. © 2013 Society of Plastics Engineers