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Preparation of ultrafine fast‐dissolving cholecalciferol‐loaded poly(vinyl pyrrolidone) fiber mats via electrospinning
Author(s) -
Li Xiaoqiang,
Lin Lin,
Zhu Yanan,
Liu Wanwan,
Yu Tianshi,
Ge Mingqiao
Publication year - 2013
Publication title -
polymer composites
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.577
H-Index - 82
eISSN - 1548-0569
pISSN - 0272-8397
DOI - 10.1002/pc.22402
Subject(s) - electrospinning , nanofiber , differential scanning calorimetry , materials science , fourier transform infrared spectroscopy , scanning electron microscope , chemical engineering , composite number , nuclear chemistry , polymer chemistry , composite material , cholecalciferol , polymer , chemistry , calcium , physics , engineering , thermodynamics , metallurgy
Abstract This study presents a method for incorporating cholecalciferol of a poorly water‐soluble vitamin into poly(vinyl pyrrolidone) fibers by electrospinning. The poorly water‐soluble vitamin was incorporated into water‐soluble polymeric matrix of nanofibers with the rapid evaporation of solvent during the electrospinning process. The scanning electron microscope (SEM) images showed that the diameter of nanofibers is range of 0.2‐2.9 μm. The physicochemical properties of the composite nanofibers were characterized by using Fourier‐transform infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC). 82.1 % and 51.9 % of cholecalciferol was released in the first 20 s from the composite nanofibers with a drug‐to‐PVP ratio of 1:4 and 1:2, respectively. POLYM. COMPOS., 2013 © 2013 Society of Plastics Engineers