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Tumefactive demyelination in pediatrics: An unusual late neurological complication of hematopoietic stem cell transplant
Author(s) -
Haldorai Meena,
Kamila Gautam,
Gupta Aditya Kumar,
Meena Jagdish Prasad,
Jauhari Prashant,
Jana Manisha,
Kumar Atin,
Brijwal Megha,
Chakrabarty Biswaroop,
Gulati Sheffali,
Seth Rachna
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29318
Subject(s) - medicine , complication , hemiparesis , hematopoietic stem cell transplantation , stem cell , sibling , myeloid leukemia , hematopoietic stem cell , haematopoiesis , radiological weapon , pathophysiology , immune system , pediatrics , surgery , pathology , immunology , transplantation , lesion , psychology , developmental psychology , biology , genetics
Immune‐mediated demyelination is a rare posttransplant complication. Here, we report an 8.5‐year‐old boy who developed left hemiparesis, 18 months post matched sibling donor hematopoietic stem cell transplant (HSCT) for relapsed acute myeloid leukemia and was diagnosed to have tumefactive demyelination. The diagnosis was established based on clinical and radiological features. The complete resolution of the lesions with steroids further established the immune‐mediated pathophysiology.