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Molecular features of non‐anaplastic peripheral T‐cell lymphoma in children and adolescents
Author(s) -
AuYeung Rex K. H.,
Richter Julia,
Iaccarino Ingram,
Abramov Dmitriy,
Bacon Chris M.,
Balagué Olga,
d'Amore Emanuele S. G.,
SimonitschKlupp Ingrid,
Hebeda Konnie,
Nakazawa Atsuko,
Oschlies Ilske,
Kontny Udo,
Woessmann Wilhelm,
Burkhardt Birgit,
Klapper Wolfram
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29285
Subject(s) - medicine , anaplastic large cell lymphoma , lymphoma , peripheral t cell lymphoma , t cell lymphoma , not otherwise specified , virus , t cell , oncology , pathology , immunology , immune system
Non‐anaplasticperipheral T‐cell lymphomas (PTCL) are rare tumors in children, adolescents, and young adults (CAYA) with poor prognosis and scarce genetic data. We analyzed lymphoma tissue from 36 patients up to 18 years old with PTCL, not otherwise specified (PTCL‐NOS), hepatosplenic T‐cell lymphoma, Epstein–Barr virus (EBV)‐positive T‐lymphoproliferative diseases, subcutaneous panniculitis‐like T‐cell lymphoma, and other PTCL types. Twenty‐three patients (64%) had at least one genetic variant detectable, including TET2 , KMT2C , PIK3D , and DMNT3A . TP53 and RHOA variants, commonly found in adults, were not identified. Eight of 20 (40%) CAYA PTCL‐NOS had no detectable mutations. The genetic findings suggest that CAYA PTCL differ from adult cases.