Premium
Adjuvant chemoradiation for high‐grade cardiac leiomyosarcoma in a child: Case report and review of literature
Author(s) -
JanopaulNaylor James,
Kanter Kirk R.,
Flampouri Stella,
Nguyen Vivi,
Olson Thomas A.,
Eaton Bree R.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29241
Subject(s) - medicine , ifosfamide , palpitations , leiomyosarcoma , anorexia , radiation therapy , surgery , radiology , chemotherapy , cisplatin
A 13‐year‐old healthy girl presented with dizziness and palpitations, found to have a left atrial mass. An 8‐cm tumor was removed en bloc. Pathology confirmed grade 3 leiomyosarcoma with multifocal positive margins. She received adjuvant ifosfamide and doxorubicin, followed by concurrent proton radiotherapy and ifosfamide. Radiotherapy included 66 Gy (RBE) in 33 fractions to the operative bed. Prospectively graded toxicities included Grade 2 esophagitis and Grade 1 anorexia, dermatitis, and fatigue. She completed six cycles of ifosfamide. Two years post operation, she had no evidence of disease, intermittent palpitations with normal cardiac function, and no other cardiopulmonary or esophageal symptoms.