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Impact of central nervous system‐directed treatment on competence and adjustment among children in early cancer survivorship
Author(s) -
Winning Adrien M.,
Moscato Emily L.,
Lehmann Vicky,
Keim Madelaine C.,
Rausch Joseph R.,
Lipak Keagan G.,
Himelhoch Alexandra C.,
Murphy Lexa K.,
Prussien Kemar V.,
Olshefski Randal S.,
Vannatta Kathryn,
Compas Bruce E.,
Gerhardt Cynthia A.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29220
Subject(s) - medicine , competence (human resources) , survivorship curve , social competence , central nervous system , neurosurgery , childhood cancer , pediatrics , cancer , psychiatry , psychology , social change , economics , economic growth , social psychology
Background Central nervous system (CNS)‐directed treatments can cause long‐term academic, social, and emotional difficulties for children with cancer. However, limited research has examined the emergence of problems longitudinally and has often stratified risk by diagnosis alone. Therefore, this study compared competence and adjustment in children, who did and did not receive CNS‐directed treatment, over the first 3 years following a cancer diagnosis. Procedure Mothers, fathers, and children (ages 5–18 years at diagnosis) from 217 families reported on the child's competence (academic, social) and adjustment (anxious/depressed, withdrawn/depressed) near a new cancer diagnosis or relapse and 3 years later. Children were categorized into CNS‐directed treatment ( n = 112; including cranial radiation, intrathecal chemotherapy, and/or neurosurgery) and non‐CNS‐directed treatment ( n = 105) groups. Results At enrollment, there were few differences in competence and emotional adjustment among children based on treatment or diagnostic group. At 3 years, mothers and fathers reported poorer social competence for the CNS‐directed treatment group, and fathers reported poorer school competence for the CNS‐directed treatment group. Over time, father ratings of social competence increased for the non‐CNS‐directed treatment group, but not the CNS‐directed treatment group. While father ratings of academic competence declined for the CNS‐directed treatment group, mother ratings declined the most for children diagnosed with a brain tumor. All children demonstrated higher anxious/depressed scores over time. Conclusions CNS‐directed treatment may be a valuable indicator to identify childhood cancer survivors at risk for poor competence during early survivorship. Follow‐up screening and supportive services are recommended, as well as additional longitudinal research.