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Epstein–Barr virus‐induced sickle hepatopathy
Author(s) -
Towerman Alison S.,
Wilson David B.,
Hulbert Monica L.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29196
Subject(s) - medicine , cholestasis , disease , virus , autoimmunity , immunology , pediatrics , gastroenterology
Sickle hepatopathy comprises a spectrum of disorders that vary in severity. Intravascular sickling and sinusoidal occlusion are the principal drivers of sickle hepatopathy, but infection or autoimmunity can act as triggers. We describe two cases of acute sickle hepatopathy initiated by primary Epstein–Barr virus (EBV) infection, a previously unreported association. The first case entailed a 14‐year‐old girl with hemoglobin SC (HbSC) disease who developed hepatic sequestration crisis that responded to a simple transfusion of erythrocytes. The second case was that of a 16‐year‐old boy with HbSC disease who experienced life‐threatening intrahepatic cholestasis with multiorgan failure.