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Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low‐ and intermediate‐grade gliomas
Author(s) -
Heitzer Andrew M.,
Kahalley Lisa S.,
Minard Charles G.,
Stafford Claire,
Grosshans David R.,
Okcu M. Fatih,
Raghubar Kimberly P.,
Gragert Marsha,
McCurdy Mark,
Warren Emily H.,
Gomez Jocelyn,
Ris M. Douglas,
Paulino Arnold C.,
Chintagumpala Murali
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29096
Subject(s) - neurocognitive , medicine , radiation therapy , pediatrics , cognition , psychiatry
The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low‐ and intermediate‐grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0–14.7) and the median age at PRT was 9.9 years (range 4.2–17.0). Patients' neurocognitive performance did not change on any measure following PRT ( p ≥ .142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.