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ε‐Aminocaproic acid versus tranexamic acid in children undergoing complex cranial vault reconstruction for repair of craniosynostosis
Author(s) -
Borst Alexandra J.,
Bonfield Christopher M.,
Deenadayalan Poornachanda S.,
Le Chi H.,
Xu Meng,
Sobey Jenna H.,
Reddy Srijaya K.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29093
Subject(s) - tranexamic acid , medicine , antifibrinolytic , aminocaproic acid , cranial vault , craniosynostosis , anesthesia , blood transfusion , perioperative , surgery , retrospective cohort study , blood loss , skull
Complex cranial vault reconstruction (CCVR) for pediatric craniosynostosis is a high blood loss surgery, for which antifibrinolytic agents have been shown to reduce bleeding and transfusion requirements. The relative efficacy of ε‐aminocaproic acid (EACA) versus tranexamic acid (TXA) has not yet been evaluated in this population. The aim of this retrospective study was to compare perioperative blood loss and transfusion in CCVR patients receiving EACA versus TXA. In a CCVR cohort of 95 children, 47 received EACA and 48 received TXA. We found no differences in demographics, adverse outcomes, calculated blood loss (CBL), or transfusion requirements between the two antifibrinolytic groups.