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Cumulative burden of chronic health conditions among adolescent and young adult survivors of childhood cancer: Identification of vulnerable groups at key medical transitions
Author(s) -
Ehrhardt Matthew J.,
Williams AnnaLynn M.,
Liu Qi,
Hudson Scholle Sarah,
Bhakta Nickhill,
Yasui Yutaka,
Robison Leslie L.,
Hudson Melissa M.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.29030
Subject(s) - medicine , confidence interval , young adult , childhood cancer , cohort , cumulative incidence , survivorship curve , cancer , cohort study , pediatrics , gerontology
The cumulative burden of chronic health conditions as childhood cancer survivors transition to adult health care and insurance systems is unknown. We estimated the cumulative burden ( N = 4612 survivors, 625 controls) in the St. Jude Lifetime Cohort. At 18 and 26 years old, survivors experienced (per 100 individuals) an average of 22.3 (95% confidence interval [CI]: 17.2–27.4) and 40.3 (95% CI: 34.8–45.8) disabling conditions versus 3.5 (95% CI: 2.0–5.0) and 5.7 (95% CI: 3.7–7.7) in controls, and 128.7 (95% CI: 119.5–137.8) and 240.5 (95% CI: 229.9–251.0) lower severity conditions versus 12.4 (95% CI: 8.9–16.0) and 51.3 (95% CI: 43.1–59.4) in controls. Survivors experience a high cumulative burden at key health care transition ages, underscoring the need to optimize access to care.