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Complexity index in sarcoma and genomic grade index gene signatures in rhabdomyosarcoma of pediatric and adult ages
Author(s) -
Ferrari Andrea,
Iannó Maria Federica,
Carenzo Andrea,
Fortunato Orazio,
Casanova Michela,
Chiaravalli Stefano,
Bergamaschi Luca,
Bertulli Rossella,
Cattaneo Francesca,
Collini Paola,
Trama Annalisa,
Sozzi Gabriella,
Massimino Maura,
De Cecco Loris,
Gasparini Patrizia
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28987
Subject(s) - medicine , rhabdomyosarcoma , mitotic index , cohort , sarcoma , oncology , soft tissue sarcoma , overall survival , histology , pathology , genetics , mitosis , biology
Background Rhabdomyosarcoma (RMS), the most frequent soft‐tissue sarcoma in childhood, shows extensive heterogeneity in histology, site and age of onset, clinical course, and prognosis. Adolescents and young adults (AYA) with RMS form a subgroup of patients whose survival lacks behind that of children while diagnosed with histologically similar tumors. Procedures A 67‐gene prognostic signature related to chromosome integrity, mitotic control, and genome complexity in sarcomas (CINSARC) is considered a powerful tool for identifying tumors with a highly metastatic potential. With this study, we investigated the prognostic value of CINSARC signature on a cohort of 48 pediatric (PEDs) and AYAs‐RMS. Results CINSARC resulted not significantly correlated with age, suggesting other determinants to be responsible for that difference in survival. It remained a significant prognostic variable in both the groups of PEDs and AYAs. Also, genomic grade index signature was tested on the same cohort and showed very similar results with CINSARC. Conclusions Our study showed that CINSARC correlated with outcome in RMS patients and may be potentially considered a tool to predict outcome, and so stratify RMS patients.