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Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: A survey by the European Retinoblastoma Group (EURbG)
Author(s) -
DittnerMoormann Sabine,
Reschke Madlen,
Abbink Floor C. H.,
Aerts Isabelle,
Atalay Hatice Tuba,
Fedorovna Bobrova Nadezhda,
Biewald Eva,
Brecht Ines B.,
Caspi Shani,
Cassoux Nathalie,
Castela Guilherme,
Diarra Yelena,
Duncan Catriona,
Ebinger Martin,
Garcia Aldana David,
Hadjistilianou Doris,
Kepák Tomáš,
Klett Artur,
Kiratli Hayyam,
Maka Erika,
Opocher Enrico,
PawinskaWasikowska Katarzyna,
Rascon Jelena,
Russo Ida,
RutynowskaPronicka Olga,
Sábado Álvarez Constantino,
Pacheco Sonsoles San Roman,
Svojgr Karel,
Timmermann Beate,
VishnevskiaDai Vicktoria,
Eggert Angelika,
RitterSovinz Petra,
Bechrakis Nikolaos E.,
Jenkinson Helen,
Moll Annette,
Munier Francis L.,
Popovic Maja Beck,
Chantada Guillermo,
Doz François,
Ketteler Petra
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28963
Subject(s) - medicine , retinoblastoma , enucleation , adjuvant , optic nerve , adjuvant therapy , oncology , radiation therapy , surgery , ophthalmology , chemotherapy , biochemistry , chemistry , gene
Advanced intraocular retinoblastoma can be cured by enucleation, but spread of retinoblastoma cells beyond the natural limits of the eye is related to a high mortality. Adjuvant therapy after enucleation has been shown to prevent metastasis in children with risk factors for extraocular retinoblastoma. However, histological criteria and adjuvant treatment regimens vary and there is no unifying consensus on the optimal choice of treatment. Method Data on guidelines for adjuvant treatment in European retinoblastoma referral centres were collected in an online survey among all members of the European Retinoblastoma Group (EURbG) network. Extended information was gathered via personal email communication. Results Data were collected from 26 centres in 17 countries. Guidelines for adjuvant treatment were in place at 92.3% of retinoblastoma centres. There was a consensus on indication for and intensity of adjuvant treatment among more than 80% of all centres. The majority of centres use no adjuvant treatment for isolated focal choroidal invasion or prelaminar optic nerve invasion. Patients with massive choroidal invasion or postlaminar optic nerve invasion receive adjuvant chemotherapy, while microscopic invasion of the resection margin of the optic nerve or extension through the sclera are treated with combined chemo‐ and radiotherapy. Conclusion Indications and adjuvant treatment regimens in European retinoblastoma referral centres are similar but not uniform. Further biomarkers in addition to histopathological risk factors could improve treatment stratification. The high consensus in European centres is an excellent foundation for a common European study with prospective validation of new biomarkers.