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Disease‐specific hospitalizations among 5‐year survivors of Wilms tumor: A Nordic population‐based cohort study
Author(s) -
Høgsholt Stine,
Asdahl Peter Haubjerg,
Bonnesen Trine Gade,
Holmqvist Anna Sällfors,
MadanatHarjuoja Laura,
Tryggvadottir Laufey,
Bautz Andrea,
Albieri Vanna,
Green Daniel,
Winther Jeanette Falck,
Hasle Henrik
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28905
Subject(s) - medicine , wilms' tumor , population , cohort , confidence interval , pediatrics , cohort study , cancer , kidney disease , environmental health
Background With modern therapy, over 90% of Wilms tumor patients can expect to become long‐term survivors, and focus on morbidity and late effects become increasingly important. We provide a novel evaluation and insight to subsequent hospitalizations in 5‐year survivors of Wilms tumor. Methods As part of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study, we identified 5‐year survivors of Wilms tumor. Based on stratified random sampling, we constructed a population comparison cohort. Outcomes of interest were overall hospitalizations; hospitalizations for specific organ systems and disease‐specific categories. Standardized hospitalization rate ratios (SHRR) and absolute excess risks (AER) were calculated. Results We included 913, 5‐year survivors of Wilms tumor and 152 231 population comparisons. Survivors of Wilms tumor had an increased overall risk of being hospitalized (SHRR 1.8; 95% confidence interval (CI) 1.7‐2.0). The hospitalization risk was increased within all major organ systems: urinary and genital organs (SHRR 2.5; 95% CI 2.1‐3.0), endocrine (SHRR 2.5; 95% CI 1.9‐3.3), cardiovascular (SHRR 2.2; 95% CI 1.7‐2.9), and gastrointestinal (SHRR 1.5; 95% CI 1.3‐1.8). Risks for specific diseases are reported in the study. Conclusions Survivors of Wilms tumor had higher risks than population comparisons for a wide range of diseases, with the highest risks seen for urinary, endocrine, and cardiovascular disorders. Five to 20 years after the Wilms tumor diagnosis, 43% of survivors had been hospitalized at least once versus 29% of population comparisons. The overall AER was 2.3, which translates into 0.2 extra hospitalizations in 10 years for every Wilms tumor survivor.