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Use of cardiac radiation therapy as bridging therapy to CAR‐T for relapsed pediatric B‐cell acute lymphoblastic leukemia
Author(s) -
Marquez Cesar P.,
MontielEsparza Raul,
Hui Caressa,
Schultz Liora M.,
Davis Kara L.,
Hoppe Richard T.,
Donaldson Sarah S.,
Ramakrishna Sneha,
Hiniker Susan M.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28870
Subject(s) - medicine , chimeric antigen receptor , radiation therapy , bone marrow , lymphoblastic leukemia , disease , leukemia , oncology , immunotherapy , cancer
The use of radiotherapy as bridging therapy to chimeric antigen receptor T‐cell therapy (CAR‐T) in pre‐B acute lymphoblastic leukemia (B‐ALL) has been minimally explored. Here, we present a boy with B‐ALL who relapsed after allogeneic bone marrow transplant with disseminated disease, including significant symptomatic cardiovascular and gastrointestinal (GI) involvement. The cardiac and GI leukemic infiltrates were successfully treated with bridging radiation therapy (BRT) prior to CAR‐T infusion. Using this approach, he successfully tolerated CAR‐T with no evidence of disease or sequelae on 3‐month follow‐up. This is the first reported case of safe and effective delivery of cardiac BRT in B‐ALL.