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Risk factors for steroid‐induced affective disorder in children with leukemia
Author(s) -
Muriel Anna C.,
Burgers Darcy E.,
Treyball Annika N.,
Vrooman Lynda M.,
Adolf Esmeralda,
Samsel Chase
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28847
Subject(s) - medicine , family history , psychiatry , psychiatric history , pediatrics , retrospective cohort study , cohort , trisomy , anxiety , biology , genetics
Corticosteroids are essential to treating childhood acute lymphoblastic leukemia (ALL), and can cause significant neuropsychiatric side effects. This retrospective chart review is a preliminary exploration of characteristics associated with psychiatry consultation and steroid‐induced affective disorder (SIAD) during ALL treatment. Of 125 ALL patients (ages 1‐10 years), 56 (44.8%) received psychiatry consultation. Thirty‐nine (31.2%) of the total cohort were diagnosed with SIAD. SIAD was significantly associated with family psychiatric history, but not with steroid exposure, CNS radiation, sociodemographic factors, developmental delay, Trisomy 21, or prior psychiatric history. Gathering family psychiatric history may help identify children at increased risk of SIAD.