Premium
Multidisciplinary management of endocrinopathies and treatment‐related toxicities in patients with Bloom syndrome and cancer
Author(s) -
Fein Levy Carolyn,
Presswala Lubaina S.,
Slomovic Alana,
Stiefel Jessica,
SchulmanRosenbaum Rifka
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28815
Subject(s) - medicine , bloom syndrome , exacerbation , chemotherapy , malignancy , cancer , pediatrics , population , intensive care medicine , multidisciplinary approach , oncology , helicase , rna , biochemistry , chemistry , environmental health , gene , social science , sociology
The treatment of malignancy in cancer predisposition syndromes that also confer exquisite sensitivity to standard chemotherapy and radiation regimens remains a challenge. Bloom syndrome is one such disorder that is caused by a defect in DNA repair, predisposing to the development of early‐onset age‐related medical conditions and malignancies. We report on two patients with Bloom syndrome who responded well to chemotherapy despite significant alterations to standard protocols necessitated by hypersensitivity. Both patients experienced severe toxicities and exacerbation of endocrine comorbidities during chemotherapy. A multidisciplinary team of oncologists and endocrinologists is best suited to care for this patient population.