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Bone marrow necrosis in pediatric malignancies: 10‐Year retrospective review and review of literature
Author(s) -
LozanoChinga Michell,
Draper Lauren,
George Tracy I.,
Agarwal Archana M.,
Dansie David M.,
Maese Luke
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28806
Subject(s) - medicine , bone marrow , malignancy , retrospective cohort study , lymphoma , necrosis , neuroblastoma , hematologic malignancy , pathology , leukemia , radiology , oncology , biology , genetics , cell culture
Bone marrow necrosis (BMN) is a rare pathologic finding, but when encountered is most often associated with malignancy. In adults, its presence correlates with an inferior prognosis, however in children the prognostic implication is unclear. We performed a retrospective review of 3,760 bone marrow specimens in patients ≤18 years over a 10‐year period. BMN was identified in less than 1% of specimens and only in patients with leukemia, lymphoma, or neuroblastoma. BMN contributed to a delay in diagnosis; however, advanced medical imaging may serve as a tool to localize nonnecrotic areas for bone marrow sampling, facilitating an expedited diagnosis.