Premium
Six‐step etoposide desensitization protocol: A pediatric, adolescent, and young adult case series
Author(s) -
Stockton Winifred,
Lam Fionna,
Nguyen Theresa,
Nguyen Tran,
Kirov Ivan
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28795
Subject(s) - desensitization (medicine) , medicine , etoposide , regimen , protocol (science) , economic shortage , anesthesia , surgery , chemotherapy , pathology , receptor , alternative medicine , linguistics , philosophy , government (linguistics)
Etoposide administration can be complicated by hypersensitivity reactions. Desensitization may provide a strategy to prevent hypersensitivity recurrence. One challenge with desensitization is regimen complexity. This case series describes 12 pediatric, adolescent, and young adult patients who received a simplified six‐step etoposide desensitization protocol. This protocol contains 50% fewer titration steps compared with previously described protocols and eliminates infusion rate changes during titration. Simplified titration may minimize risk of error during administration and improve safety. This protocol was tolerated by 92% of patients. Given increasing frequency and duration of drug shortages, a simplified desensitization protocol provides a valuable treatment option.