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Aerodigestive adverse effects during intravenous pentamidine infusion for Pneumocystis jirovecii pneumonia prophylaxis
Author(s) -
Savaşan Süreyya,
George Amy,
Sokolowski Catherine,
McGraw Bettina Joi,
Rademacher Hillary
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28714
Subject(s) - medicine , adverse effect , nausea , vomiting , tingling , pneumonia , pentamidine , anesthesia , pneumocystis jirovecii , aspiration pneumonia , surgery
Abstract Aerodigestive adverse effects (AD‐AE) during intravenous pentamidine (IV‐P) infusion for Pneumocystis jiroveci pneumonia prophylaxis are uncommon in retrospective chart review studies. We conducted a survey in patients on IV‐P, which included 31 specific questions. Twenty‐five patients were included in the analysis; AD‐AE were observed in 22 (88%) with recurrence of symptoms in 88% participants with subsequent infusions. Five leading symptoms were congestion (48%), lip tingling (32%), nausea (28%), tongue tingling (24%), vomiting, and throat swelling (17%); multiple symptoms were reported in 72% of the patients. In conclusion, AD‐AE of IV‐P infusion are common, self‐limited, and tend to be recurrent.