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Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing
Author(s) -
Lin Timothy A.,
Ludmir Ethan B.,
Liao KaiPing,
McAleer Mary Frances,
Bishop Andrew J.,
Grosshans David,
McGovern Susan,
Woodhouse Kristina D.,
Paulino Arnold C.,
Yeboa Debra Nana
Publication year - 2020
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28685
Subject(s) - medicine , radiation therapy , sarcoma , ewing's sarcoma , cancer , overall survival , oncology , cancer therapy , volume (thermodynamics) , pathology , physics , quantum mechanics
In the treatment of localized Ewing sarcoma (EWS), delays in local therapy are known to adversely impact overall survival (OS). However, the role of treatment center volume in EWS outcomes, and the interaction between center volume and local therapy timing with definitive radiotherapy, remains unknown. Using the National Cancer Database, we demonstrate that treatment at the lowest EWS volume centers is associated with reduced OS, explained partly by higher rates of delayed local therapy. Treatment at the highest volume centers results in improved OS, but appears independent of radiotherapy timing. Future efforts to improve care for EWS patients across treatment centers are imperative.