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Systemic viral infection in children receiving chemotherapy for acute leukemia
Author(s) -
BuusGehrig Constanze,
Bochennek Konrad,
Hennies Marc T.,
Klingebiel Thomas,
Groll Andreas H.,
Lehrnbecher Thomas
Publication year - 2020
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28673
Subject(s) - medicine , leukemia , parvovirus , hematopoietic stem cell transplantation , chemotherapy , incidence (geometry) , cytomegalovirus , acute leukemia , immunology , ganciclovir , herpes simplex virus , transplantation , virus , viral disease , virology , herpesviridae , human cytomegalovirus , physics , optics
Systemic viral diseases frequently occur in allogeneic hematopoietic stem cell transplantation, but data in children receiving chemotherapy for acute leukemia are scarce. We therefore collected and analyzed the published data on symptomatic infection from cytomegalovirus, herpes simplex virus, varicella zoster virus, parvovirus B19, or adenovirus in pediatric acute leukemia. Reports on 68 children were identified, of whom 16 patients have died from the infection. Further studies have to (1) evaluate the true incidence of these infections in pediatric acute leukemia, (2) their impact on outcome, and (3) whether a subpopulation of patients could benefit from screening and prophylactic strategies.