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VIVA (vinorelbine, ifosfamide, vincristine, actinomycin‐D): A new regimen in the armamentarium of systemic therapy for high‐risk rhabdomyosarcoma
Author(s) -
Ferrari Andrea,
Chiaravalli Stefano,
Zecca Marco,
Recupero Santina,
Pascale Silvia,
Bergamaschi Luca,
Casanova Michela
Publication year - 2020
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28649
Subject(s) - medicine , ifosfamide , vinorelbine , regimen , vincristine , rhabdomyosarcoma , chemotherapy , oncology , cyclophosphamide , chemotherapy regimen , surgery , sarcoma , etoposide , pathology , cisplatin
The study reports the treatment feasibility, and secondly efficacy, of a novel chemotherapy regimen, which adds vinorelbine to the ifosfamide‐vincristine‐actinomycin‐D combination (VIVA regimen), used in four patients with high‐risk rhabdomyosarcoma. All patients received nine cycles of the VIVA regimen followed by maintenance chemotherapy with vinorelbine and cyclophosphamide. All patients experienced significant hematological toxicity, but no other major complications (in particular neurotoxicity) or required treatment dose modifications. We observed a major response after three cycles in all patients, and they remained alive after a median follow up of 11 months from diagnosis.