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Acute lymphoblastic leukemia
Author(s) -
Chang John HanChih,
Poppe Matthew M.,
Hua ChiaHo,
Marcus Karen J.,
Esiashvili Natia
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28371
Subject(s) - medicine , radiation therapy , oncology , lymphoblastic leukemia , hematopoietic stem cell transplantation , chemotherapy , regimen , leukemia , stem cell , transplantation , biology , genetics
The survival of patients with acute lymphoblastic leukemia (ALL) has improved significantly with the use of intensive multimodality treatment regimens including chemotherapy, high‐dose chemotherapy and stem cell rescue, and radiation therapy when indicated. This report summarizes the treatment strategies, especially radiation therapy in the Children's Oncology Group for children with ALL. Currently, radiation therapy is only indicated for children with high‐risk CNS involvement at diagnosis or relapse, testicular relapse and as part of the conditioning regimen for hematopoietic stem cell transplantation. Future research strategies regarding the indications for and dosages of radiation therapy and novel radiation techniques are discussed.