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Osteosarcoma
Author(s) -
Eaton Bree R.,
Schwarz Rudolf,
Vatner Ralph,
Yeh Brian,
Claude Line,
Indelicato Daniel J.,
Laack Nadia
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28352
Subject(s) - medicine , osteosarcoma , radiation therapy , chemotherapy , induction chemotherapy , multidisciplinary approach , surgical resection , surgery , oncology , general surgery , pathology , social science , sociology
Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology. Standard treatment involves multiagent induction chemotherapy followed by surgical resection for local tumor control and consolidation local control to metastatic sites. Radiotherapy is reserved for cases with a marginal or incomplete resection or for definitive treatment in the case of unresectable disease. We present supporting data for the role of chemotherapy, surgery, and radiation therapy.