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Late effects of radiation therapy in pediatric patients and survivorship
Author(s) -
Palmer Joshua D.,
Tsang Derek S.,
Tinkle Christopher L.,
Olch Arthur J.,
Kremer Leontien C.M.,
Ronckers Cecile M.,
Gibbs Iris C.,
Constine Louis S.
Publication year - 2021
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28349
Subject(s) - medicine , radiation therapy , survivorship curve , cancer survivorship , childhood cancer , late effect , quality of life (healthcare) , disease , cancer , pediatric cancer , pediatric oncology , intensive care medicine , pediatrics , surgery , nursing
Abstract Advances in multimodality therapy have led to childhood cancer cure rates over 80%. However, surgery, chemotherapy, and radiotherapy may lead to debilitating or even fatal long‐term effects among childhood survivors beyond those inflicted by the primary disease process. It is critical to understand, mitigate, and prevent these late effects of cancer therapy to improve the quality of life of childhood cancer survivors. This review summarizes the various late effects of radiotherapy and acknowledges the Pediatric Normal Tissue Effects in the Clinic (PENTEC), an international collaboration that is systematically analyzing the association between radiation treatment dose/volume and consequential organ toxicities, in developing children as a basis to formulate recommendations for clinical practice of pediatric radiation oncology. We also summarize initiatives for survivorship and surveillance of late normal tissue effects related to radiation therapy among long‐term survivors of childhood cancer treated in the past.