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Hurthle cell carcinoma in childhood: A retrospective analysis of five cases and review of pediatric literature
Author(s) -
Zirilli Giuseppina,
Valenzise Mariella,
Dionigi Gianlorenzo,
Tuccari Giovanni,
Romeo Carmelo,
Campennì Alfredo,
Corrias Andrea,
Tuli Gerdi,
Ieni Antonio,
Pajno Giovanni Battista,
Wasniewska Malgorzata
Publication year - 2020
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28300
Subject(s) - medicine , thyroid cancer , retrospective cohort study , pediatrics , population , disease , thyroid carcinoma , cancer , thyroiditis , cohort , thyroid , environmental health
Abstract Background the available studies on Hurthle cell carcinoma (HCC) in pediatric age are scarce and based on isolated case reports. Aims of the present study were to review the available pediatric literature on HCC (2000‐2019), to describe the cohort of children with this cancer histotype, and to estimate its relative prevalence in pediatric age. Procedure We retrospectively reconstructed an HCC course in five patients < 19 years who were identified in our departments during the period 2000‐2019, and we reviewed the available pediatric studies on this differentiated thyroid cancer (DTC) variant. Results HCC occurred with a relative prevalence of 5.8% at a median chronological age of 12.5 years. None of HCC patients exhibited, at diagnosis, thyroid dysfunction, extensive lateral neck disease, or distant metastases, and all showed a persistent remission over time. Three patients showed, at diagnosis, antecedents of other diseases (Hashimoto's thyroiditis, neurofibromatosis type 1, and osteosarcoma). Conclusions (1) In childhood, the relative prevalence of HCC among different thyroid cancer histotypes is 5.8%, that is close to the one previously reported both in the general population and in other less numerous children's cohorts; (2) HCC may develop even early, at the age of 7; (3) in childhood, HCC does not seem to have a more aggressive behavior when compared with other DTC histotypes; (4) antecedents of other diseases are not infrequent in the history of children with HCC.