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Pure pediatric ovarian immature teratomas: The French experience
Author(s) -
Pavone Rossana,
Dijoud Frederique,
Galmiche Louise,
Ro Vathanaksambath,
Hameury Frederic,
Sarnacki Sabine,
Orbach Daniel,
Briandet Claire,
Pasquet Maryline,
Bertrand Amandine,
Fresneau Brice,
FaureConter Cécile
Publication year - 2020
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28186
Subject(s) - medicine , stage (stratigraphy) , surgery , cystectomy , chemotherapy , grading (engineering) , ovarian cancer , bleomycin , cancer , bladder cancer , paleontology , civil engineering , engineering , biology
Objective To describe characteristics and outcome of pediatric ovarian immature teratomas (IT) to better define the place of chemotherapy. Methods Children with ovarian IT enrolled in TGM95 and TGM2013 studies were analyzed. Norris grading and International Federation of Gynecology and Obstetrics staging system were used. Results Thirty‐six cases were identified with a median age of 11 years (range = 1‐18): 35 of 36 stage I (17 stage IA, 13 stage IC, and 5 stage IX), including seven patients with gliomatosis peritonei (GP), and 1 stage IIIB (IT peritoneal implants). Centrally reviewed Norris grading was performed in 31 cases: 14 grade I and 17 grade II/III tumors. All patients underwent upfront surgery: 19 unilateral oophorectomy, 14 unilateral adnexectomy, 2 unilateral cystectomy, and 1 bilateral cystectomy. No extensive GP surgery was performed. Six patients received adjuvant vinblastin, bleomycin, and cisplatinum because of tumor rupture ( n = 5, including two patients with GP) or stage III ( n = 1). After a median follow‐up of 39.5 months (range = 6‐238), two events occurred 10 and 11 months after diagnosis: one bilateralization (initial stage IX, grade I) and one IT peritoneal relapse (initial stage IA, grade II), respectively. Both were successfully rescued by platinum‐based chemotherapy and delayed surgery. No stage IC patients treated without adjuvant chemotherapy relapsed (four grade I and three grade III). None of the seven patients with GP progressed. Five‐year event‐free survival and overall survival were 94% (95% CI = 81‐98%) and 100%. Conclusions The current series confirms the excellent prognosis of pediatric ovarian IT, arguing for conservative surgical approach in GP and against systematic adjuvant chemotherapy, even in ruptured tumors.