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Pharmacokinetics and population pharmacokinetics in pediatric oncology
Author(s) -
Sassen Sebastiaan D.T.,
Zwaan C. Michel,
der Sluis Inge M.,
Mathôt Ron A.A.
Publication year - 2020
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.28132
Subject(s) - pharmacokinetics , medicine , population pharmacokinetics , pediatric oncology , sampling (signal processing) , population , oncology , pharmacology , cancer , computer science , environmental health , filter (signal processing) , computer vision
Pharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of heterogeneous data, and identification of variability sources. However, population pharmacokinetic reports can be complex and difficult to interpret. The aim of this article is to provide a basic explanation of population pharmacokinetics, using clinical examples from the field of pediatric oncology, to facilitate the translation of pharmacokinetic research into the daily clinic.