Premium
Evidence for BCR/ABL1‐positive T‐cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell
Author(s) -
Ragg Susanne,
Zehentner Barbara K.,
Loken Michael R.,
Croop James M.
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27829
Subject(s) - progenitor cell , chronic myelogenous leukemia , medicine , cancer research , fluorescence in situ hybridization , breakpoint cluster region , myeloid , fusion gene , abl , cd34 , leukemia , myeloid leukemia , stem cell , progenitor , immunology , biology , microbiology and biotechnology , gene , receptor , genetics , tyrosine kinase , chromosome
BCR‐ABL1‐positive leukemias have historically been classified as either chronic myelogenous leukemia or Ph+ acute lymphoblastic leukemia. Recent analyses suggest there may be a wider range of subtypes. We report a patient with BCR‐ABL1 fusion positive T‐cell ALL with a previously undescribed cell distribution of the fusion gene. The examination of sorted cells by fluorescence in situ hybridization showed the BCR‐ABL1 fusion in the malignant T cells and a subpopulation of the nonmalignant B cells, but not nonmalignant T cells or myeloid or CD34+ progenitor cells providing evidence that the fusion may have occurred in an early lymphoid progenitor.