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Critical review of the management of primary central nervous nongerminomatous germ cell tumors
Author(s) -
Abu Arja Mohammad H.,
Bouffet Eric,
Finlay Jonathan L.,
AbdelBaki Mohamed S.
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27658
Subject(s) - medicine , radiation therapy , germ cell tumors , chemotherapy , central nervous system , oncology , adverse effect , germ cell , disease , clinical trial , intensive care medicine , bioinformatics , biochemistry , chemistry , gene , biology
Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Outcomes for patients with relapsed disease remain poor. There is an obvious need to incorporate molecular studies within prospective clinical trials that will likely lead to the incorporation of targeted, more effective future treatment strategies.