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Successful treatment of metastatic cerebral recurrence of pleuropulmonary blastoma
Author(s) -
Nakano Yoshiko,
Gatell Sandra Pisa,
Schultz Kris Ann P.,
Carrillo Thais Murciano,
Fujisaki Hiroyuki,
Okada Keiko,
Horiike Masaki,
Nakamura Tetsuro,
Watanabe Yusuke,
Matsusaka Yasuhiro,
Sakamoto Hiroaki,
Fukushima Hiroko,
Inoue Takeshi,
Williams Gretchen M.,
Hill D. Ashley,
Hara Junichi
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27628
Subject(s) - medicine , radiation therapy , chemotherapy , regimen , central nervous system , metastasis , surgery , radiology , cancer
Abstract Pleuropulmonary blastoma (PPB) is a rare pediatric tumor. The central nervous system (CNS) is the most common site of extrathoracic metastasis. The prognosis of PPB patients with CNS metastases is dismal: most patients die within one year after recurrence. Here, we describe two patients diagnosed with PPB who developed intracranial recurrences shortly after the end of their initial treatment and were successfully treated by gross total resection, radiotherapy, and chemotherapy. Both patients are in complete remission four and three years after recurrence. Although an optimal regimen remains to be determined, these cases demonstrate that PPB with CNS metastases is potentially curable.