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Long‐term analysis of children with metastatic neuroblastoma treated in the ENSG5 randomised clinical trial
Author(s) -
Moreno Lucas,
Vaidya Sucheta J.,
Schrey Dominik,
Pinkerton C. Ross,
Lewis Ian J.,
Kearns Pamela R.,
Machin David,
Pearson Andrew D. J.
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27565
Subject(s) - medicine , hazard ratio , neuroblastoma , regimen , confidence interval , induction chemotherapy , chemotherapy , population , chemotherapy regimen , oncology , surgery , environmental health , biology , genetics , cell culture
Background The European Neuroblastoma Study Group 5 (ENSG5) trial showed that time‐intensive “rapid” induction chemotherapy (COJEC) was superior to “standard” 3‐weekly chemotherapy for children with high‐risk metastatic neuroblastoma. Long‐term outcomes of the ENSG5 trial were analysed. Procedure Patients with metastatic neuroblastoma aged ≥12 months were randomly assigned to “standard” or “rapid” induction, receiving the same chemotherapy drugs and doses. Event‐free survival (EFS) and overall survival (OS) were analysed and prognostic factors evaluated. Amongst patients surviving >5 years, a population of children with persistent metastatic disease after the end of treatment was identified and described. Results Ten‐year EFS was 18.2% (95% confidence interval: 12.2–25.2) for the “standard” arm and 26.8% (19.5–34.7) for the “rapid” arm (hazard ratio [HR] 0.85, P = 0.28). Ten‐year OS for the “standard” arm was 19.7% (13.4–26.8) and 28.3% (20.8‐36.2) for the “rapid arm” (HR 0.83, P = 0.19). There was a trend for worse EFS and OS for patients having MYCN amplification (HR 1.37 and 1.40, respectively) and those with partial and mixed response to induction (HR 1.69 and 1.75 for EFS and 1.66 and 2.00 for OS, respectively). Among 69 patients who survived >5 years, six had persistent metastatic disease after the end of treatment. Conclusion The benefit of the “rapid” induction regimen seems to be maintained in the long term, although the small number of survivors could justify the lack of statistical significance. MYCN amplification and poor metastatic response to induction could be associated with worse outcomes. A small group of patients with persistent metastatic disease that survived long term has been described.