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Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta‐analysis
Author(s) -
Zamani Martin,
Grønhøj Christian,
Schmidt Jensen Jakob,
Buchwald Christian,
Charabi Birgitte Wittenborg,
Hjuler Thomas
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27543
Subject(s) - medicine , meta analysis , mucoepidermoid carcinoma , salivary gland , cochrane library , radiation therapy , salivary gland cancer , cancer , stage (stratigraphy) , systematic review , oncology , medline , surgery , paleontology , political science , law , biology
A systematic search of PubMed, EMBASE, and the Cochrane Library for studies from 2000 to 2017 including children aged 0‐19 with salivary gland cancer was performed. In 19 studies, 749 children (median age of 14.2 years, female to male ratio of 1.4:1) were included; 72% had parotid tumors and 95% underwent surgery, of whom 65% had surgery alone and 24% with adjuvant radiotherapy. Low‐grade and stage mucoepidermoid carcinoma were the most frequent cancer. The 5‐year overall‐ and disease‐free survival was 94% and 83%. Recurrence was observed in 20% at a median of 1.1 years from diagnosis.