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Treatment of hepatic veno‐occlusive disease in children with N ‐acetylcysteine
Author(s) -
Lee Anselm Chiwai,
Aung LeLe
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27518
Subject(s) - medicine , hepatic veno occlusive disease , acetylcysteine , hepatic dysfunction , chemotherapy , transplantation , disease , gastroenterology , wilms' tumor , surgery , hematopoietic stem cell transplantation , biochemistry , chemistry , antioxidant
In our institution, hepatic veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) has been treated with N ‐acetylcysteine (NAC) since 2008—a loading dose of 150 mg/kg, followed by 12 doses of 70 mg/kg 6 hourly. Nine children were diagnosed with hepatic VOD/SOS. Hepatic VOD/SOS occurred in seven children after stem cell transplantation and two were receiving chemotherapy for Wilms tumor. Their clinical severity was classified as moderate in two and severe in seven by the European Society for Blood and Marrow Transplantation criteria. All children recovered and were discharged from 4 to 16 days after diagnosis. No side effects were observed. Intravenous NAC is an effective treatment for hepatic VOD/SOS.