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Insulin‐dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia
Author(s) -
Wolthers Benjamin Ole,
Mogensen Pernille R.,
Frandsen Thomas L.,
Abrahamsson Jonas,
Behrendtz Mikael,
Heyman Mats,
Lohi Olli,
NorénNyström Ulrika,
Ruud Ellen,
Schmiegelow Kjeld
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27437
Subject(s) - medicine , pancreatitis , acute pancreatitis , diabetes mellitus , complication , asparaginase , lymphoblastic leukemia , intensive care medicine , insulin , pediatrics , leukemia , endocrinology
Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow‐up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin‐dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.