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Adaptive behavior impaired in children with low‐grade glioma
Author(s) -
de Lande R. S. van,
MauriceStam H.,
Marchal J. P.,
Vuurden D. G. van,
Vandertop W. P,
Grootenhuis M. A.,
Schoutenvan Meeteren A. Y. N.
Publication year - 2019
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27419
Subject(s) - adaptive behavior , medicine , vineland adaptive behavior scale , motor skill , computerized adaptive testing , gross motor skill , motor impairment , pediatrics , audiology , developmental psychology , clinical psychology , psychology , psychiatry , physical medicine and rehabilitation , psychometrics
Background Adaptive behavior, i.e., the performance on daily activities required for personal and social independence, is essential to estimate in children with low‐grade glioma (LGG) since most of them are long‐term survivors. Our aim was to investigate adaptive behavior in children with LGG. Methods In a cross‐sectional study, adaptive behavior was assessed using the paper pencil version of the Parent Form of the Vineland Adaptive Behavior Scales 2nd edition (VABS‐II) testing communication, daily living skills, social skills, and motor skills. Scores of children with LGG, younger than 20 years, and diagnosed between 2004 and 2014 were compared with family controls. Correlations between clinical variables and adaptive behavior were explored. Results Fifty‐six children with LGG (median age, 12.1 years; 52% male) and 46 controls (median age, 11.0 years; 43% male) were included in the analyses. Compared with controls, the LGG group was more impaired on total adaptive behavior, communication, and motor skills and in the subdomain gross motor skills (effect sizes d , 0.64–0.86, P < 0.003). Younger age at diagnosis ( r = −0.357, P < 0.01) and chemotherapy ( r = −0.342, P < 0.05) were associated with poorer motor skills. Residual disease was associated with poorer total adaptive behavior ( r = −0.282, P < 0.05). No other significant correlations were found. Conclusion At the group level, adaptive functioning of children with LGG is impaired compared with family controls. Regular structured monitoring of adaptive behavior is recommended to be able to define the needs for tailored rehabilitation in daily life at home as well as at school.